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2002•Unpublished venueRequires access

The Origin and Etiology of Trisomy 21

Terry J Hassold, Stephanie L. Sherman

Open publisher page 7 citations

Abstract

This chapter discusses the derivation Down syndrome, and its cause. Studies indicate that errors in chromosome separation in the egg (maternal nondisjunction) are responsible for the overwhelming majority of trisomny 21 occurrences. While much is unknown about the risk factors that influence the frequency of trisomy 21, studies have linked the age of the mother with the occurrence of the disorder. The chapter also discusses other factors that can increase the risk of trisomy 21.

About this research paper

What this paper is about

This chapter discusses the derivation Down syndrome, and its cause. Studies indicate that errors in chromosome separation in the egg (maternal nondisjunction) are responsible for the overwhelming majority of trisomny 21 occurrences. While much is unknown about the risk factors that influence the frequency of trisomy 21, studies have linked the age of the mother with the occurrence of the disorder. The chapter also discusses other factors that can increase the risk of trisomy 21.

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OpenAlex reports 7 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

This chapter discusses the derivation Down syndrome, and its cause. Studies indicate that errors in chromosome separation in the egg (maternal nondisjunction) are responsible for the overwhelming majority of trisomny 21 occurrences. While much is unknown about the risk factors that influence the frequency of trisomy 21, studies have linked the age of the mother with the occurrence of the disorder. The chapter also discusses other factors that can increase the risk of trisomy 21.

Key concepts: Nondisjunction, Trisomy, Etiology, Genetics, Down syndrome, Biology, Chromosome, Aneuploidy

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