2014•The FASEB JournalRequires access
The action of photodynamic therapy on Candida species (836.10)
Anelise Cristina Osorio César Dória, Isabela Bevilacqua, Thaisa Baesso Santos, Guilherme Rodrigues Teodoro, Elizabeth Oliveira, Sônia Khouri, Renata Amadei Nicolau
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Abstract
Candida yeasts are normal commensal of human microbiota, which can cause infection in patients with predisposing factors. Photodynamic antimicrobial therapy has been employed against several microbial infections. Light, when associated with dyes, promotes microbial death in a less invasive way, reducing the treatment time. The aim of the present study was to investigated the effect of Photodynamic Therapy (PDT) with MetyleneBlue (MB) and a light emitting diode (LED), on Candida species.Cultures of C. albicans, C. glabrata, C. tropicalis, C. parapsilosis, C. krusei and C. dubliniensis weresubmmited to photodynamic therapy employing LED and Methylen blue. The number of CFU/mL was reduced in 100% for Candida glabrata , 99.57% for Candida albicans , 99.41% for Candida krusei , 97.53% for Candida dubliniensis , 97.29% for Candida tropicalis , and 96.88% for Candida parapsilosis when compared with the control group. The results showed that the PDT significantly reduced the CFU of Candida . The result of this study allows us to conclude that all Candida species tested were susceptible to the PDT treatment.