2010•Pharmaceutical Sciences EncyclopediaRequires access

Toxicogenomics in Preclinical Development

Eric A.G. Blomme, Dimitri Semizarov, Jeffrey F. Waring

Abstract

Abstract Toxicogenomics refers to a technology wherein gene expression analysis is used in the field of toxicology. Toxicogenomics is based on the relatively simple assumption that toxicants acting through a similar mechanism of action will generate similar gene expression profiles. This article discusses the importance of toxicogenomics in drug discovery and mechanistic toxicology.

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Available abstract

Key concepts: Toxicogenomics, Computational biology, Mechanism (biology), Drug development, Biology, Bioinformatics, Toxicology, Drug