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N – Methyl thiomethylation and N-Hydroxymethylation of Phthalimide

N.D. Zargar, Khaliquz Zaman Khan

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Abstract

N- Methyl thiomethyl phthalimide (I) a new compound was obtained when phthalimide was refluxed with DMSO acetic anhydride  reagent and DMSO alone at 180 o C. A different route for the synthesis of N- Hydroxy methylphthalilmide (II)with excellent yield has also been explored by this reaction. Key Words : DMSO, Acetic anhydride, Phthalimide, Methyl thiomethylation

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What this paper is about

N- Methyl thiomethyl phthalimide (I) a new compound was obtained when phthalimide was refluxed with DMSO acetic anhydride  reagent and DMSO alone at 180 o C. A different route for the synthesis of N- Hydroxy methylphthalilmide (II)with excellent yield has also been explored by this reaction. Key Words : DMSO, Acetic anhydride, Phthalimide, Methyl thiomethylation

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Available abstract

N- Methyl thiomethyl phthalimide (I) a new compound was obtained when phthalimide was refluxed with DMSO acetic anhydride  reagent and DMSO alone at 180 o C. A different route for the synthesis of N- Hydroxy methylphthalilmide (II)with excellent yield has also been explored by this reaction. Key Words : DMSO, Acetic anhydride, Phthalimide, Methyl thiomethylation

Key concepts: Phthalimide, Acetic anhydride, Yield (engineering), Reagent, Chemistry, Organic chemistry, Nuclear chemistry, Medicinal chemistry

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