Studies on the Granulation Process of Granules for Tableting with a High Speed Mixer. I. Physical Properties of Granules for Tableting.

Several kinds of theophylline granules were prepared by monitoring the power consumption of a high speed mixer while compressing them into tablets. The physical properties of the granules and their tablets were evaluated in order to investigate the optimal physical properties and granulation conditions for tableting. As a result, the granule consisting of a mixture of small agglomerates and bulk powder of similar sizes demonstrated the most favorable physical properties for tableting. Its granulation end point was at the end above first small peak of the power consumption curve.