The sheep immune response. Variation of anti-hapten and anti-carrier antibodies in the 1 and 2 immunoglobulin fractions.

The results obtained in the quantification of γ(1) and γ(2) anti-hapten (DNP) and anti-carrier (HGG) antibodies obtained weekly during 50 weeks and proceeding from a group of three Merino sheep immunized with DNP—HGG, are described. The primary and secondary response and the antibody variations in weekly repeated stimulations were studied. The anti-DNP and anti-HGG total antibodies have similar variations. γ(1) and γ(2) anti-DNP and anti-HGG antibodies do not show differences in the primary response nor in weekly repeated stimulations. In the secondary response, a high increase of γ(1) with loss of γ(2) is observed. After a certain time γ(1) decreases and γ(2) increases.