1974•Journal of Biological ChemistryOpen access

Properties of Angiotensin II Receptors in the Bovine and Rat Adrenal Cortex

Hartmut Glossmann, Albert J. Baukal, Kevin Catt

Abstract

Receptorsfor angiotensin II have been identified and characterized in bovine and rat adrenal cortex by binding studies with tritiated and monoiodinated angiotensin II.The angiotensin II binding sites of bovine adrenal cortex homogenate were enriched severalfold in a microsomal membrane fraction together with alkaline phosphatase, adenylate cyclase, 5'nucleotidase and ZlP-hydroxylase.Uptake of angiotensin II by adrenal cortex particles and adrenal cells was rapid, reaching equilibrium at 15 to 30 min in the pres-

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Key concepts: Adrenal cortex, Receptor, Endocrinology, Angiotensin II, Internal medicine, Chemistry, Biology, Medicine