Optofluidic Techniques for the Manipulation of Micro Particles: Principles and Applications to Bioanalyses

This chapter classifies optofluidic techniques into three categories, (i) fiber-based optofluidic technique; (ii) near-field optofluidic technique; and (iii) axial-type and cross-type optical chromatography. The fundamental mechanism and recent development of these optofluidic techniques are reviewed. Then, the chapter presents a novel SU-8/polydimethylsiloxane (PDMS) optofluidic chip in which an on-chip lens structure is introduced to enhance the performance of microparticle manipulation. Finally, applications of optofluidic techniques to bioanalyses are discussed. Both theoretical and experimental results have shown that the optical manipulation performance could be enhanced by the proposed on-chip lens structures, because the light beam waist radius was reduced by these lens structures. Controlled Vocabulary Terms chromatography; OBIC; symbol manipulation