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Trend of increasing levels of minimum inhibitory concentration of ciprofloxacin to Salmonella typhi.

M V Jesudason, B Malathy, Thomas John

Open publisher page 36 citations

Abstract

The minimum inhibitory concentration (MIC) of ciprofloxacin has been determined in 193 strains of S. typhi isolated during January and July each year from March 1991 to July 1995. While all strains remained within established range of susceptibility, a clear trend of increase of MIC values with time was observed. During the first four study periods, all strains had MIC values below 0.031 microgram/ml; during the fifth and sixth, 3 strains had a higher value namely 0.125 microgram/ml. During the last four, 14 strains showed MIC values of 0.25 microgram/ml. Thus an increase in MIC of ciprofloxacin to S. typhi has been observed over the years.

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What this paper is about

The minimum inhibitory concentration (MIC) of ciprofloxacin has been determined in 193 strains of S. typhi isolated during January and July each year from March 1991 to July 1995. While all strains remained within established range of susceptibility, a clear trend of increase of MIC values with time was observed. During the first four study periods, all strains had MIC values below 0.031 microgram/ml; during the fifth and sixth, 3 strains had a higher value namely 0.125 microgram/ml. During the last four, 14 strains showed MIC values of 0.25 microgram/ml. Thus an increase in MIC of ciprofloxacin to S. typhi has been observed over the years.

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OpenAlex reports 36 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

The minimum inhibitory concentration (MIC) of ciprofloxacin has been determined in 193 strains of S. typhi isolated during January and July each year from March 1991 to July 1995. While all strains remained within established range of susceptibility, a clear trend of increase of MIC values with time was observed. During the first four study periods, all strains had MIC values below 0.031 microgram/ml; during the fifth and sixth, 3 strains had a higher value namely 0.125 microgram/ml. During the last four, 14 strains showed MIC values of 0.25 microgram/ml. Thus an increase in MIC of ciprofloxacin to S. typhi has been observed over the years.

Key concepts: Ciprofloxacin, Microgram, Minimum inhibitory concentration, Salmonella typhi, Microbiology, Biology, Chemistry, Medicine

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