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Antibodies in human filariasis sera react with diethylcarbamazine.

Balaraman Ravindran, Ashok Kumar Satapathy, T Hussain, A M Pattnaik

Abstract

We demonstrate by an ELISA the presence of antibodies in human filarial sera that react with diethylcarbamazine (DEC); they appear to be primarily filarial antibodies cross-reacting with DEC skeleton, since affinity-purified DEC antibodies strongly react with Wuchereria bancrofti microfilariae. These observations indicate a possible antigenic mimicry between the drug and some parasite component.

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Available abstract

Key concepts: Diethylcarbamazine, Wuchereria bancrofti, Antibody, Filariasis, Immunology, Lymphatic filariasis, Biology, Antigen