An Occurrence of Shipping Fever Associated with Several Pathogens in Grazing Calves

Respiratory disease characterized by pyrexia, depression, nasal discharge and cough occurred in some of 254 grazing Holstein calves 1 week after their introduction into a pasture and one of them subsequently died.Myccoplasma bovirhinis, Pasteurella multocida, Pasteurella haemolytica and Parainfluenza virus type 3 were isolated from these cattle. The results of serological tests on the paired sera of these cattle showed a significant rise in antibody titers against not only these isolated organisms but also to bovineviral diarrhea-mucosal disease virus. Autopsy revealed focal pneumonia and whitish pseudomembrane in the paranasal sinuses of the cow that died. Histologically, acidophilic cytoplasmic inclusion bodies were observed in the epithelial cells of the paranasal sinuses.From these results, this disease was diagnosed as shipping fever caused by mixed infectionwith Parainfluenza virus type 3 and other pathogens.