2010•PubMedOpen access
Estradiol valerate and estradiol valerate/dienogest (natazia) tablets: the first four-phasic oral contraceptive.
Uche Anadu Ndefo, Nina Mosely
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Abstract
This article focuses upon the May 2010 FDA approved estradiol valerate and estradiol valerate/dienogest (Natazia) tablets which is the first four-phasic oral contraceptive. It discusses: the indications and usage the clinical pharmacology including mechanism of action and pharmacokinetics clinical trials adverse drug effects drug interactions contraindications warnings dosage and administration and cost.