2001•Pharmaceutical technologyRequires access

Systemic drug delivery via the buccal mucosal route

Amir Hossein Shojaei, Richard K. Chang, Xiaodi Guo, Beth Burnside, Richard A. Couch

Abstract

Within the oral mucosal cavity, the buccal region offers an attractive route of administration for systemic drug delivery. The mucosa has a rich blood supply and is permeable to many pharmacologically active agents. The objective of this article is to review buccal drug delivery by discussing the structure and environment of the oral mucosa and highlighting the experimental methods used in the assessment of buccal drug permeation and absorption. The review also assesses the current status of buccal permeation enhancers as well as buccal drug delivery systems.

About this research paper

What this paper is about

Why it matters

OpenAlex reports 74 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Buccal administration, Buccal mucosa, Drug, Drug delivery, Medicine, Oral cavity, Pharmacology, Dentistry