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2014•PubMedOpen access

Prevalence of microcytosis in neonates: a cross-sectional study in Tehran.

Nasrin Khalesi, Nastaran Khosravi, Mohammad Reza Rezaee, Leila Amini

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Abstract

BACKGROUND: Identification of α thalassemia (α thal) a common cause of microcytosis during neonatal periods is an important step prevent unnecessary interventions. Thus, low the mean corpuscular volume (MCV) and the mean corpuscular hemoglobin (MCH) may consider as α-thalassemia key detection points. The present study aimed to determine the prevalence of microcytosis among neonates who born in Tehran, Iran. METHODS: Cord blood samples were collected from 1001 newborns after birth in labor room and their red blood cell parameters were investigated. RESULTS: MCV was 114.2 fl (95% CI: 113.5-114.9) and twenty three neonates (2.3%) had MCV less than 94 fL that classified as microcytosis and 4 (0.40%) had both low MCH and MCV. CONCLUSION: Low MCV especially in normal Hb newborns may hints for α thal detection.

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BACKGROUND: Identification of α thalassemia (α thal) a common cause of microcytosis during neonatal periods is an important step prevent unnecessary interventions. Thus, low the mean corpuscular volume (MCV) and the mean corpuscular hemoglobin (MCH) may consider as α-thalassemia key detection points. The present study aimed to determine the prevalence of microcytosis among neonates who born in Tehran, Iran. METHODS: Cord blood samples were collected from 1001 newborns after birth in labor room and their red blood cell parameters were investigated. RESULTS: MCV was 114.2 fl (95% CI: 113.5-114.9) and twenty three neonates (2.3%) had MCV less than 94 fL that classified as microcytosis and 4 (0.40%) had both low MCH and MCV. CONCLUSION: Low MCV especially in normal Hb newborns may hints for α thal detection.

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Available abstract

BACKGROUND: Identification of α thalassemia (α thal) a common cause of microcytosis during neonatal periods is an important step prevent unnecessary interventions. Thus, low the mean corpuscular volume (MCV) and the mean corpuscular hemoglobin (MCH) may consider as α-thalassemia key detection points. The present study aimed to determine the prevalence of microcytosis among neonates who born in Tehran, Iran. METHODS: Cord blood samples were collected from 1001 newborns after birth in labor room and their red blood cell parameters were investigated. RESULTS: MCV was 114.2 fl (95% CI: 113.5-114.9) and twenty three neonates (2.3%) had MCV less than 94 fL that classified as microcytosis and 4 (0.40%) had both low MCH and MCV. CONCLUSION: Low MCV especially in normal Hb newborns may hints for α thal detection.

Key concepts: Microcytosis, Mean corpuscular volume, Medicine, Cord blood, Mean corpuscular hemoglobin, Pediatrics, Thalassemia, Obstetrics

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Prevalence of microcytosis in neonates: a cross-sectional study in Tehran. — Research Paper | ScholarLens