ScholarLens Back to search
2001•Birkhäuser Basel eBooksRequires access

Transgenic mice overexpressing the shortest human tau isoform develop a progressive tauopathy

Takeshi Ishihara, Ming Hong, Bin Zhang, John Q. Trojanowski, Virginia M.‐Y. Lee

Open publisher page 1 citations

Abstract

Tau is an abundant microtubule-associated protein in the CNS that is implicated in the pathogenesis of frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP17), progressive supranuclear palsy (PSP), amyotrophic lateral sclerosis/parkinsonismdementia complex (ALS/PDC) of Guam, Alzheimer’s disease (AD) and a number of other neurodegenerative diseases known as tauopathies [1–4].Tauopathies are characterized neuropathologically by numerous inclusions formed by aggregated paired helical filaments (PHFs) and/or straight filaments composed of aberrantly phosphorylated tau proteins (PHFtau) in selectively vulnerable neurons and glial cells throughout widespread regions of the CNS [1–4]. These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

About this research paper

What this paper is about

Tau is an abundant microtubule-associated protein in the CNS that is implicated in the pathogenesis of frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP17), progressive supranuclear palsy (PSP), amyotrophic lateral sclerosis/parkinsonismdementia complex (ALS/PDC) of Guam, Alzheimer’s disease (AD) and a number of other neurodegenerative diseases known as tauopathies [1–4].Tauopathies are characterized neuropathologically by numerous inclusions formed by aggregated paired helical filaments (PHFs) and/or straight filaments composed of aberrantly phosphorylated tau proteins (PHFtau) in selectively vulnerable neurons and glial cells throughout widespread regions of the CNS [1–4]. These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Why it matters

OpenAlex reports 1 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Tau is an abundant microtubule-associated protein in the CNS that is implicated in the pathogenesis of frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP17), progressive supranuclear palsy (PSP), amyotrophic lateral sclerosis/parkinsonismdementia complex (ALS/PDC) of Guam, Alzheimer’s disease (AD) and a number of other neurodegenerative diseases known as tauopathies [1–4].Tauopathies are characterized neuropathologically by numerous inclusions formed by aggregated paired helical filaments (PHFs) and/or straight filaments composed of aberrantly phosphorylated tau proteins (PHFtau) in selectively vulnerable neurons and glial cells throughout widespread regions of the CNS [1–4]. These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Key concepts: Tauopathy, Progressive supranuclear palsy, Frontotemporal dementia, Amyotrophic lateral sclerosis, Tau protein, Neuroscience, Gene isoform, Genetically modified mouse

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Transgenic mice overexpressing the shortest human tau isoform develop a progressive tauopathy — Research Paper | ScholarLens