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EFFECT OF FLUORIDE INTOXICATION ON LIPID PEROXIDATION AND ANTIOXIDANT SYSTEMS IN RATS

YM Shivarajashankara, AR Shivashankara, Kumar M. R. Bhat

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Abstract

SUMMARY: The effect of fluoride intoxication on lipid peroxidation and anti- oxidant systems in the blood, brain, and liver of rats was studied. Twelve one- month-old albino rats were administered 100-ppm fluoride (as NaF) in their drinking water for four months. In the red blood cells the levels of malondial- dehyde (MDA) and glutathione (GSH) increased, along with the activity of glu- tathione peroxidase (GSH-Px), but the activity of superoxide dismutase (SOD) decreased. In the plasma the level of ascorbic acid increased while that of uric acid decreased. In the brain and liver, MDA and GSH levels increased, as did the activities of GSH-Px and glutathione S-transferase (GST). The level of ascorbic acid increased in the brain, but it decreased in the liver. These re- sults suggest that fluoride enhances lipid peroxidation in the red blood cells, brain and liver of rats and causes increased or decreased enzyme activity as- sociated with free radical metabolism.

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SUMMARY: The effect of fluoride intoxication on lipid peroxidation and anti- oxidant systems in the blood, brain, and liver of rats was studied. Twelve one- month-old albino rats were administered 100-ppm fluoride (as NaF) in their drinking water for four months. In the red blood cells the levels of malondial- dehyde (MDA) and glutathione (GSH) increased, along with the activity of glu- tathione peroxidase (GSH-Px), but the activity of superoxide dismutase (SOD) decreased. In the plasma the level of ascorbic acid increased while that of uric acid decreased. In the brain and liver, MDA and GSH levels increased, as did the activities of GSH-Px and glutathione S-transferase (GST). The level of ascorbic acid increased in the brain, but it decreased in the liver. These re- sults suggest that fluoride enhances lipid peroxidation in the red blood cells, brain and liver of rats and causes increased or decreased enzyme activity as- sociated with free radical metabolism.

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Available abstract

SUMMARY: The effect of fluoride intoxication on lipid peroxidation and anti- oxidant systems in the blood, brain, and liver of rats was studied. Twelve one- month-old albino rats were administered 100-ppm fluoride (as NaF) in their drinking water for four months. In the red blood cells the levels of malondial- dehyde (MDA) and glutathione (GSH) increased, along with the activity of glu- tathione peroxidase (GSH-Px), but the activity of superoxide dismutase (SOD) decreased. In the plasma the level of ascorbic acid increased while that of uric acid decreased. In the brain and liver, MDA and GSH levels increased, as did the activities of GSH-Px and glutathione S-transferase (GST). The level of ascorbic acid increased in the brain, but it decreased in the liver. These re- sults suggest that fluoride enhances lipid peroxidation in the red blood cells, brain and liver of rats and causes increased or decreased enzyme activity as- sociated with free radical metabolism.

Key concepts: Lipid peroxidation, Ascorbic acid, Chemistry, Glutathione, Uric acid, Antioxidant, Glutathione peroxidase, Endocrinology

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