2009•The Thai Journal of Pharmaceutical SciencesOpen access

Effects of the standard extract of Centella asiatica (ECa233) on rat hepatic cytochrome P450

Kornphimol Kulthong, H. Mayuree, Nuansri Niwattisaiwong, Khemchat Apipalakul, Songpol Chevapat, Somsong Lawanprasert

Abstract

Centella asiatica (L.) Urban (Umbelliferae) has been used traditionally in various diseases. The aim of this study was to examine subchronic effects of the standard extract of c. asiatica (ECa233) on hepatic xenobiotic/drug metabolizing enzymes, particul...

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Key concepts: CYP2E1, CYP1A2, CYP3A, Pharmacology, Microsome, Cytochrome P450, IC50, Chemistry