2011•PubMedOpen access

[Clinical utility of serum tumor markers in lung cancer].

Xiao Zhao, Mengzhao Wang

Abstract

Lung cancer shows a tendency of higher incidence and higher mortality in recent years, but the overall 5-year survival rate is less than 15%. Serum tumor markers of lung cancer play an important role in early diagnosis, determining of pathology types, staging, evaluation of response, and prognosis of lung cancer. In this review, 6 most important markers were reviewed, including neuron-specific enolase (NSE), pro-gastrin-releasing peptide (ProGRP), cytokeratin 19 fragments (Cyfra 21-1), tissue polypeptide antigen (TPA), squamous cell carcinoma associated antigen (SCC-Ag), carcinoembryonic antigen (CEA).

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Key concepts: Carcinoembryonic antigen, Enolase, Lung cancer, Medicine, Cytokeratin, Tumor marker, Pathology, Oncology