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Contraindicated antiretroviral drug combinations.

Abe M. Macher, David L. Thomas, Sindy M. Paul

Open publisher page 1 citations

Abstract

The proper implementation of combination antiretroviral treatment regimens is fundamental to successful therapeutic outcomes for patients with HIV/AIDS. Unfortunately, some patients are still being prescribed contraindicated antiretroviral regimens that include: 1. stavudine plus zidovudine; 2. Invirase plus two nucleoside analog reverse transcriptase inhibitors (NRTIS); 3. zalcitabine plus didanosine; 4. zalcitabine plus stavudine; and, 5. zalcitabine plus lamivudine. Inappropriate regimens such as these either have limited effectiveness or potential severe toxicity.

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What this paper is about

The proper implementation of combination antiretroviral treatment regimens is fundamental to successful therapeutic outcomes for patients with HIV/AIDS. Unfortunately, some patients are still being prescribed contraindicated antiretroviral regimens that include: 1. stavudine plus zidovudine; 2. Invirase plus two nucleoside analog reverse transcriptase inhibitors (NRTIS); 3. zalcitabine plus didanosine; 4. zalcitabine plus stavudine; and, 5. zalcitabine plus lamivudine. Inappropriate regimens such as these either have limited effectiveness or potential severe toxicity.

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Available abstract

The proper implementation of combination antiretroviral treatment regimens is fundamental to successful therapeutic outcomes for patients with HIV/AIDS. Unfortunately, some patients are still being prescribed contraindicated antiretroviral regimens that include: 1. stavudine plus zidovudine; 2. Invirase plus two nucleoside analog reverse transcriptase inhibitors (NRTIS); 3. zalcitabine plus didanosine; 4. zalcitabine plus stavudine; and, 5. zalcitabine plus lamivudine. Inappropriate regimens such as these either have limited effectiveness or potential severe toxicity.

Key concepts: Zalcitabine, Didanosine, Stavudine, Lamivudine, Zidovudine, Medicine, Reverse-transcriptase inhibitor, Nucleoside analogue

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