Combination of ropivacaine with pethidine, morphine or tramadol for postoperative PCEA.

Objective To compare the analgesic effects and adverse effects of ropivacaine combined with pethidine,morphine or tramadol for postoperative patient control epidural analgesia(PCEA).Methods90 ASA Ⅰ~Ⅱ patients scheduled for elective abdominal or legs surgeries were randomly divided into 3 groups.Group A(30 cases):ropivacaine 200 mg+ pethidine 50 mg+ ondansetron 4 mg;Group B(30 cases):ropivacaine 200 mg+morphine 5 mg+ ondansetron 4 mg;Group C(cases):ropivacaine 200mg+ tramadol 600 mg+ ondansetron 4 mg.The VAS,Ramsay sedation scores,HR,BP,SpO2 and adverse effects were observed at 4 th,8 th,24 th,48 th hour after operation.ResultsVAS in group A was lower than those in group B and group C(P0.05),and there was no significant difference in VAS between group B and group C(P0.05).Ramsay sedation scores of group C were higher than those of group A and group B(P0.05).There was no respiratory arrest in 3 groups.Incidences of nausea,vomiting in group A were lower than those in group B and C.ConclusionRopivacaine combined with pethidine for postoperative PCEA has a better analgesic effect than ropivacaine combined with morphine or tramadol.