2015•Bioorganic & Medicinal ChemistryOpen access

Evaluation of transition-state mimics in a superior BACE1 cleavage sequence as peptide-mimetic BACE1 inhibitors

Yasunao Hattori, Kazuya Kobayashi, Ayaka Deguchi, Yukie Nohara, Tomomi Akiyama, Kenta Teruya, Akira Sanjoh, Atsushi Nakagawa, Eiki Yamashita, Kenichi Akaji

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Key concepts: Scissile bond, Chemistry, Isostere, Stereochemistry, Cleavage (geology), Substituent, Transition state analog, Active site

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Evaluation of transition-state mimics in a superior BACE1 cleavage sequence as peptide-mimetic BACE1 inhibitors — Research Paper | ScholarLens