1979•PubMedOpen access

Occurrence of antibodies to single-stranded DNA in ANA negative patients.

Charles A. Wasicek, Peter J. Maddison, Morris Reichlin

Abstract

Five patients with clinical features of a connective tissue disease most suggestive of systemic lupus erythematosus were found to have a negative ANA by conventional screening at 1/20 dilution on mouse liver. However, significant titres of antibodies to single-stranded DNA were detected using a double antibody radioimmunoassay. Thus, certain patients have antibodies to DNA restricted to single-stranded determinants as detected by radioimmunoassay with single-stranded DNA as antigen and a negative ANA test.

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Available abstract

Key concepts: Radioimmunoassay, Antibody, Immunology, Anti-nuclear antibody, Antigen, DNA, Connective tissue disease, Lupus erythematosus