2015•International Letters of Chemistry Physics and AstronomyOpen access

Malononitrile: A Versatile Active Methylene Group

Ravindra S. Dhivare, Shankarsing Sardarsing Rajput

Abstract

The title role of malononitrile in the development of Knoevenagel condensation of organic synthesis and their new findings are explored in this review. The active methylene group of malononitriles is very important attacking part in the heterocyclic conversions and also having a great potency towards several microbial and biological systems.

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Key concepts: Malononitrile, Knoevenagel condensation, Methylene, Chemistry, Combinatorial chemistry, Organic chemistry, Catalysis