2006•STM:n Hallinnonalan avoin julkaisuarkisto (Julkari)Requires access

Accumulation of hepatic acetaldehyde and reduced alcohol drinking in transgenic mice carrying the Oriental variant of the human aldehyde dehydrogenase 2 gene

Jiingjau Jeng, David Goldman, Eriksson Cjp, Kallarakal At, Wang Tty, Henry Weiner, Song Bj

Abstract

The major enzymes involved in ethanol metabolism in mammalian liver are the alcohol dehydrogenases (ADH) and the mitochondrial aldehyde dehydrogenase (ALDH2). ADH isozymes oxidize ethanol into acetaldehyde and the mitochondrial, low Km ALDH2 catalyzes the conversion of acetaldehyde to acetic acid. Both human ADH and ALDH2 utilize NAD as a cofactor for the catalysis and both are polymorphic with alleles with different kinetic properties (Harada et al., 1982; Goedde et al., 1983). The most notable Abstract

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Key concepts: ALDH2, Acetaldehyde, Aldehyde dehydrogenase, Alcohol dehydrogenase, Isozyme, Ethanol metabolism, Biochemistry, NAD+ kinase