2003•Han-guk hyeonmigyeong hakoeji/Applied microscopyRequires access

The Role of Protein Kinase C in the Cardiac Injury Induced by Skin Burn

Hye-Jung Moon, Hyun-Gug Cho, Won-Hark Park

Abstract

The aim of the present study was to assess the role of protein kinase C (PKC) in the development of cardiac injury following scald burn. Sprague-Dawley rats were induced a scald burn a 15% total body surface area. Phorbol 12-myristate 13-acetate (PMA, 2 mg/kg) and bisindolylmaleimide (BIS, 0.05 mg/kg) were immediately administered i.p. after burn injury. 5 h and 24 h later, heart was removed and examined biochemical assay, ultrastructural changes and stereological analysis. The activity of serum aspartate aminotransferase was significantly increased at 5h (p

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Key concepts: Bisindolylmaleimide, Burn injury, Protein kinase C, Total body surface area, Phorbol, Protein kinase A, Chemistry, Endocrinology