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Hepatotoxicity of mebendazole. Relationship with serum concentrations of the drug.

A Bekhti, Jean Pirotte

Abstract

We report the case of a 47-year-old female patient, suffering from multiple hydatid cysts of the liver, in whom hepatitis developed after mebendazole treatment. Clinical manifestations of hypersensitivity were absent. A correlation was found between serum mebendazole concentrations and the degree of cytolysis; this is compatible with a direct hepatotoxic effect of mebendazole.

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Key concepts: Mebendazole, Medicine, Drug, Gastroenterology, Echinococcosis, Hepatitis, Cytolysis, Internal medicine