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CALLA-negative, TdT- and CD7-positive acute lymphoblastic leukemia: a phenotype associated with poor prognosis.
Giulio Rossi, Maria Antonietta Aloe Spiriti, Arturo Cafolla, Roberto Gastaldi, F. Lo Coco, Manuela Lopez, Matteo Luciani, Daniela Pasqualetti, Anna Maria Testi, Franco Mandelli
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Abstract
Eight ALL patients displaying a CD7+, Tdt+, CD10-, T MoAbs-, myeloid MoAbs-, AP+ phenotype are described. Some patients showed well-known risk factors such as cytogenetic abnormalities, high WBC count, mediastinal mass, and/or organomegalies. The clinical behaviour was very poor and only one patient is in CR and off therapy. Therefore such a pre-T phenotype, although sometimes associated with the other risk factors, could be considered a poor prognosis phenotype.