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Reduction of GABA-and substance P-immunoreactivities in spinal dorsal horn by capsaicin

赵志奇, 魏锋, 杨焕乔

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Abstract

γ-aminobutyric acid (GABA)-containing neurons are densely located in laminae Ⅰ—Ⅱ of the spinal cord where substance P (SP)-containing primary afferent C fibers terminate. By the antibody microprobe technique, we found that capsaicin, a chemical irritant selectively activating C fibers, significantly produced the release of SP in lamina Ⅱ. The

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γ-aminobutyric acid (GABA)-containing neurons are densely located in laminae Ⅰ—Ⅱ of the spinal cord where substance P (SP)-containing primary afferent C fibers terminate. By the antibody microprobe technique, we found that capsaicin, a chemical irritant selectively activating C fibers, significantly produced the release of SP in lamina Ⅱ. The

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Available abstract

γ-aminobutyric acid (GABA)-containing neurons are densely located in laminae Ⅰ—Ⅱ of the spinal cord where substance P (SP)-containing primary afferent C fibers terminate. By the antibody microprobe technique, we found that capsaicin, a chemical irritant selectively activating C fibers, significantly produced the release of SP in lamina Ⅱ. The

Key concepts: Capsaicin, Substance P, Chemistry, Spinal cord, Nociception, Dorsum, Afferent, French horn

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Reduction of GABA-and substance P-immunoreactivities in spinal dorsal horn by capsaicin — Research Paper | ScholarLens